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中国南方汉族人群ZCCHC14基因多态性与小动脉闭塞性卒中的关系
作者: 李建立、江东东、刘柳余、蒋怡颖、罗曼
单位:广西医科大学第一附属医院神经内科 南宁530021、广西壮族自治区江滨医院神经内二科、广西心脑血管疾病临床医学研究中心
关键词: ZCCHC14、单核苷酸多态性、缺血性脑卒中、小动脉闭塞
分类号:R743
出版年·卷·期(页码):2020·46·第 2 期(80-84)
摘要:
目的 探讨中国南方汉族人群ZCCHC14基因rs12445022位点单核苷酸多态性(single nucleotide polymorphism,SNP)与小动脉闭塞(small artery occlusion,SAO)性卒中的关系.方法 纳入中国南方汉族人群SAO患者121例及同期正常对照者140名,收集一般临床资料,采用SNaPshot方法检测基因型,logistic回归分析基因多态性与疾病的相关性.结果 SAO组与对照组ZCCHC14基因rs12445022位点AA、GA、GG基因型(2.5%vs.1.4%,18.2%vs.11.4%,79.3%vs.87.2%)及A、G等位基因频率(11.6%vs.7.1%,88.4%vs.92.9%)比较,差异无统计学意义(P>0.05).rs12445022位点经调整高血压史、糖尿病史、吸烟史、LDL-C等混杂因素后,在显性模型(AA+GA vs.GG)中与SAO显著相关(校正OR=2.12,95%CI:1.02~4.40,P=0.044).结论 ZCCHC14基因SNP rs12445022多态性与中国南方汉族人群SAO发病风险有关.
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