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TNIK基因多态性与抗精神病药疗效关联研究☆
作者: 李瑶婧、徐青青、禹顺英
单位:上海交通大学医学院附属精神卫生中心遗传研究室 上海200030
关键词: TNIK、基因多态性、抗精神病药
分类号:R749.3
出版年·卷·期(页码):2020·46·第 1 期(19-23)
摘要:
目的 探讨中国汉族人群精神分裂症患者肿瘤坏死因子受体相关因子-2和NCK相互作用蛋白激酶(traf2-and NCK-interacting kinase,TNIK)基因rs2088885、rs7627954及rs13065441与抗精神病药疗效的关系.方法 纳入精神分裂症患者260例,予以单一抗精神病药(包括利培酮、喹硫平、阿立哌唑、奥氮平及奋乃静)治疗6周,以阳性和阴性症状量表(positive and negative syndrome scale,PANSS)减分率评定药物疗效(减分率≥50%为有效,<50%为未显效),采用sequenom massarray="" p="">0.05),rs13065441位点等位基因C(=4.601,P=0.034)及基因型C/T(=4.601,P=0.032)在有效组中的分布频率较未显效组更高,但经Bonferroni校正后差异无统计学意义(P>0.05).rs2088885与rs7627954构成的AC及CT两种单倍型分布频率在两组间无统计学差异(P>0.05).在共显性、显性、隐性、超显性、加性遗传模式下,有效组和未显效组间TNIK rs2088885和rs7627954基因型分布差异均无统计学意义(P>0.05).结论 未发现TNIK基因rs2088885、rs7627954及rs13065441与抗精神病药疗效间具有关联.
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