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反复发作抑郁症与5-羟色胺1A和5-羟色胺2A受体基因多态性的关联性研究☆
作者: 姚静、庞剑月、何瑾、冯婷婷、张淑绮、李恒芬
单位:郑州大学第一附属医院精神医学科 郑州450052
关键词: 反复发作抑郁症、5-羟色胺受体、标签SNPs、广义多因子降维法
分类号:R749.4
出版年·卷·期(页码):2020·46·第 1 期(13-18)
摘要:
目的 探讨反复发作抑郁症(recurrent major depressive disorder,RMDD)与5-羟色胺1A受体(5-hydroxytryptamine 1A receptor,5-HTR1A)和5-羟色胺2A受体(5-hydroxytryptamine 2A receptor,5-HTR2A)基因单核苷酸多态性(single nucleotide polymorphisms,SNPs)的关系.方法 选取5-HTR1A(rs878567)和5-HTR2A(rs1328683、rs17068986、rs9534495)基因的4个标签SNPs(tagging SNPs,tagSNPs),使用Sequenom质谱分析对1030例RMDD患者(病例组)和851名健康对照(对照组)的DNA样本进行基因分型检测,采用关联分析和广义多因子降维法(generalized multifactor dimensionality reduction,GMDR)分析RMDD与4个tagSNPs的关系.结果 5-HTR2A rs17068986基因型(=8.727,P=0.013)及等位基因(=4.955,P=0.025)频率在两组间分布差异均具有统计学意义;病例组T等位基因频率高于对照组(55.3%vs.51.6%,OR=1.158,95%CI:1.018~1.318).5-HTR2A rs17068986基因型分布最符合显性遗传模型(P=0.003),病例组TT+TC基因型频率高于对照组(81.0%vs.75.4%,OR=1.410,95%CI:1.120~1.760).GMDR分析显示四阶交互模型(rs878567、rs1328683、rs17068986、rs9534495)为最优模型(P=0.001,1000次置换检验),交叉验证一致性为10/10,检验精确度为0.534.结论 5-HTR2A rs17068986可能存在或连锁RMDD的易感位点,5-HTR1A和5-HTR2A基因的交互作用也与RMDD的发病有一定关系.
参考文献:

[1] 邓彭,赵晓锋,庞剑月,刘倩,张洪艳,李恒芬.CREB1和BDNF基因多态性交互作用与反复发作抑郁症的关联研究[J].中华行为医学与脑科学杂志,2017,(10).865-869.

[2] 包玲,胡晓华,王宗琴,高作慧,冯映映,李东霞,丁佩.慢性应激抑郁大鼠脑内5-羟色胺受体mRNA表达[J].脑与神经疾病杂志,2017,(1).14-17.

[3] 张婧,刘海燕,姚志剑,卢青.5-羟色胺2A受体基因T102C多态性与抑郁症患者大脑灰质密度的相关性[J].中国神经精神疾病杂志,2011,(4).210-213.

[4] Jiarun Yang,Xueyan Zhao,Jingsong Ma,Zhengxue Qiao,Xiuxian Yang,Erying Zhao,Bo Ban,Xiongzhao Zhu,Depin Cao,Yanjie Yang,Xiaohui Qiu.The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.[J].2019,172.

[5] David M Howard,Mark J Adams,Toni-Kim Clarke,Jonathan D Hafferty,Jude Gibson,Masoud Shirali,Jonathan R I Coleman,Saskia P Hagenaars,Joey Ward,Eleanor M Wigmore,Clara Alloza,Xueyi Shen,Miruna C Barbu,Eileen Y Xu,Heather C Whalley,Riccardo E Marioni,David J Porteous,Gail Davies,Ian J Deary,Gibran Hemani,Klaus Berger,Henning Teismann,Rajesh Rawal,Volker Arolt,Bernhard T Baune,Udo Dannlowski,Katharina Domschke,Chao Tian,David A Hinds,23andMe Research Team,Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium,Maciej Trzaskowski,Enda M Byrne,Stephan Ripke,Daniel J Smith,Patrick F Sullivan,Naomi R Wray,Gerome Breen,Cathryn M Lewis,Andrew M McIntosh.Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.[J].2019,(3).343-352.

[6] Dong Han,Zhengxue Qiao,Dong Qi,Jiarun Yang,Xiuxian Yang,Jingsong Ma,Lin Wang,Xuejia Song,Erying Zhao,Jian Zhang,Yanjie Yang,Xiaohui Qiu.Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder.[J].2019,218.

[7] Richard Border,Emma C Johnson,Luke M Evans,Andrew Smolen,Noah Berley,Patrick F Sullivan,Matthew C Keller.No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.[J].2019,(5).376-387.

[8] Steinberg  Stacy,Andlauer  Till M. F.,Mattheisen  Manuel,Knowles  James A.,Hinds  David A.,Posthuma  Danielle,Trubetskoy  Vassily,Hougaard  David M.,Cichon  Sven,Crowley  Cheynna A.,Pettersson  Erik,Li  Qingqin S.,Jorgenson  Eric,Rietschel  Marcella,Nyholt  Dale R.,Mullins  Niamh,Pedersen  Marianne Giortz,Buttenschon  Henriette N.,McGuffin  Peter,Li  Yun,Voelzke  Henry,Adams  Mark J.,Quiroz  Jorge A.,Qvist  Per,Thomson  Pippa A.,Van der Auwera  Sandra,Craddock  Nick,Wu  Yang,Metspalu  Andres,Werge  Thomas,Lind  Penelope A.,Berger  Klaus,Paciga  Sara A.,Saxena  Richa,Medland  Sarah E.,Traylor  Matthew,McGrath  Patrick,McIntosh  Andrew M.,Wray  Naomi R.,Martin  Nicholas G.,Hannon  Eilis,DePaulo  J. Raymond,Pistis  Giorgio,Nordentoft  Merete,Lucae  Susanne,Smit  Johannes H.,Maier  Wolfgang.Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression[J].2018,(5).

[9] Peterson  Roseann E.,Cai  Na,Bigdeli  Tim B.,Li  Yihan,Reimers  Mark,Nikulova  Anna,Webb  Bradley T.,Bacanu  Silviu-Alin,Riley  Brien P.,Flint  Jonathan,Kendler  Kenneth S..The Genetic Architecture of Major Depressive Disorder in Han Chinese Women[J].2017,(2).

[10] Dasiel O  Borroto-Escuela,Xiang  Li,Alexander O  Tarakanov,David  Savelli,Manuel  Narváez,Kirill  Shumilov,Yuniesky  Andrade-Talavera,Antonio  Jimenez-Beristain,Bartosz  Pomierny,Zaida  Díaz-Cabiale,Riccardo  Cuppini,Patrizia  Ambrogini,Maria  Lindskog,Kjell  Fuxe.Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition.[J].2017,(8).4779-4789.

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